PACE4 in Thyroid Cancer

Robert Day

Status: Completed

Conditions: Thyroid Nodule

Treatments: Diagnostic Test: Immunohistochemistry

Study type: Observational

Funder types: Other

Identifiers

NCT03160482

2017-1620

Details and patient eligibility

About

The investigation of thyroid nodules is limited by the fact that up to 49% of the fine needle aspirations (FNA) performed are of "indeterminate cytological signification". Moreover, no fully reliable molecular marker for thyroid cancer have been described. The goal of this project is to study the expression of a specific kind of protein convertase in benign and in malignant thyroid nodules to determine its potential as a biomarker.

Full description

Patients that underwent thyroidectomy at the CIUSSS de l'Estrie-CHUS will be recruited and classified according to the pathological diagnosis. An immunohistochemistry technique, developed and calibrated for the specific protein convertase studied, will be undertaken. Results will be interpreted by a specialized pathologist.

Enrollment: 39 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men of women, aged 18-100 y.-o.
• History of subtotal or total thyroidectomy at the "Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke" (CIUSSS de l'Estrie - CHUS) between January 2010 and May 2016.

Exclusion criteria

• Refusal to participate to the study.
• Unavailability of the formalin-fixed, paraffin-embedded tissues.
• Uncertain pathological diagnosis.

Trial design

39 participants in 9 patient groups

Papillary carcinoma, classical variant

Treatment:

Diagnostic Test: Immunohistochemistry

Follicular carcinoma

Treatment:

Diagnostic Test: Immunohistochemistry

Colloid nodule

Treatment:

Diagnostic Test: Immunohistochemistry

Hyperplastic nodule

Treatment:

Diagnostic Test: Immunohistochemistry

Adenomatoid nodule

Treatment:

Diagnostic Test: Immunohistochemistry

Follicular adenoma

Treatment:

Diagnostic Test: Immunohistochemistry

Papillary carcinoma, follicular variant

Treatment:

Diagnostic Test: Immunohistochemistry

Medullary carcinoma

Treatment:

Diagnostic Test: Immunohistochemistry

Lymphocytic thyroiditis

Treatment:

Diagnostic Test: Immunohistochemistry