Package of Interventions After Recovering From Moderate Acute Malnutrition

The Washington University

Status: Completed

Conditions: Malnutrition

Treatments: Dietary Supplement: Lipid Nutrient Supplement; Drug: Albendazole; Drug: Sulfadoxine-pyrimethamine; Drug: Zinc; Other: Insecticide-treated bednet

Study type: Interventional

Funder types: Other

Identifiers

NCT02351687

MFU2014

Details and patient eligibility

About

Children who recover from moderate acute malnutrition in Malawi remain at high risk for relapse or death in the year following recovery. This cluster-randomized trial will evaluate a package of affordable, safe, proven interventions specifically targeted to this population of children in an attempt to decrease their risk of relapse or death following recovery from moderate acute malnutrition. These children will be followed for a year following recovery to assess rates of relapse and mortality.

Enrollment: 1,499 patients

Sex: All

Ages: 6 to 59 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• recovered from moderate acute malnutrition, as defined by mid-upper arm circumference (MUAC) of 11.5-12.4 cm

Exclusion criteria

• not permanent resident in vicinity of site
• severe chronic illness
• receiving other supplementary food or participating in other research

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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1,499 participants in 2 patient groups

No Intervention

No Intervention group

Description:

No specific intervention given after recovery from moderate acute malnutrition.

Package of interventions

Experimental group

Description:

Package of interventions given after recovery from moderate acute malnutrition -- includes lipid-nutrient supplement for 2 months, malaria chemoprophylaxis for 3 months during malaria season, an insecticide-treated bed net, a one-time albendazole treatment, and 14 days of zinc.

Treatment:

Dietary Supplement: Lipid Nutrient Supplement

Other: Insecticide-treated bednet

Drug: Zinc

Drug: Albendazole

Drug: Sulfadoxine-pyrimethamine