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Paclitaxel, Carboplatin, and Oral Etoposide Followed by Weekly Paclitaxel in High Grade Neuroendocrine Carcinoma

S

SCRI Development Innovations

Status and phase

Completed
Phase 2

Conditions

Neuroendocrine Carcinoma

Treatments

Drug: Paclitaxel
Drug: Etoposide
Drug: Carboplatin

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT00193531
SCRI MISC 16

Details and patient eligibility

About

carboplatin and etoposide, followed by maintenance therapy with weekly paclitaxel in patients with poorly differentiated neuroendocrine carcinomas. We hope to identify a "standard treatment" for this unusual group of patients who are not usually eligible for clinical trials.

Full description

Upon determination of eligibility, patients will be receive:

  • Paclitaxel + Carboplatin + Etoposide

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

To be included in this study, you must meet the following criteria:

  • Metastatic poorly differentiated neuroendocrine carcinoma
  • Unknown primary site
  • Able to perform activities of daily living with minimal assistance
  • Measurable or evaluable disease
  • Adequate bone marrow, liver functions and kidney function
  • No previous treatment with chemotherapy
  • Understand the nature of this study and give written informed consent.

Exclusion criteria

You cannot participate in this study if any of the following apply to you:

  • Age < 18 years
  • Previous malignancy within five years
  • Women pregnant or lactating
  • Recent history of cardiovascular disease
  • Meningeal metastases

Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have.

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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