Pain After Laparoscopic Cholecystectomy

Baylor College of Medicine

Status: Completed

Conditions: Postoperative Pain

Treatments: Drug: Sevoflurane; Drug: Propofol; Drug: Desflurane; Drug: Isoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT00983918

H-24815

Details and patient eligibility

About

To the investigators' knowledge, no study has looked at differences in postoperative pain when comparing maintenance of anesthesia with isoflurane, desflurane, sevoflurane, and propofol in laparoscopic cholecystectomy. The investigators' hypothesis is that total intravenous anesthesia with propofol will lead to less postoperative pain in the first 24 hours after laparoscopic cholecystectomy when compared to maintenance of anesthesia with isoflurane, desflurane or sevoflurane.

PURPOSE

To find out if maintenance of anesthesia with propofol leads to less postoperative pain after laparoscopic cholecystectomy when compared to maintenance of anesthesia with isoflurane, desflurane, or sevoflurane.

Enrollment: 80 patients

Sex: All

Ages: 18 to 64 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patient ages 18-64
2. American Society of Anesthesiology Physical Status I, II or III
3. Inpatients scheduled to undergo laparoscopic cholecystectomy at Ben Taub General Hospital

Exclusion criteria

1. Open cholecystectomy - excluded due to increased levels of pain in open procedures
2. Scheduled for ambulatory surgery
3. Renal dysfunction (Serum Cr > 1.2) - excluded due to potential altered metabolism of anesthetic and pain medications
4. Allergy to any of the study medications or anesthetic agents
5. Chronic opioid analgesic use at home - excluded due to potential difficulty in assessing pain caused by the procedure alone
6. Patient inability to properly describe postoperative pain to investigators (language barrier, dementia, delirium, psychiatric disorder)
7. Patient or surgeon refusal

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 4 patient groups

Desflurane

Active Comparator group

Description:

General Anesthesia with Desflurane

Treatment:

Drug: Desflurane

Sevoflurane

Active Comparator group

Description:

General Anesthesia with Sevoflurane

Treatment:

Drug: Sevoflurane

Isoflurane

Active Comparator group

Description:

General Anesthesia with Isoflurane

Treatment:

Drug: Isoflurane

Propofol

Active Comparator group

Description:

General Anesthesia with Propofol

Treatment:

Drug: Propofol