Pain After Laparoscopy Results From the Incision, Manipulation of the Abdominal Organs, and Retained CO2(Back Pain)

Sohag University

Status and phase: Unknown; Phase 2

Conditions: Post Operative Pain, Acute

Treatments: Drug: intraperitoneal Magnesium sulfate; Drug: intravenous magnesium sulfate

Study type: Interventional

Funder types: Other

Identifiers

NCT05186467

2007

Details and patient eligibility

About

Postoperative pain after laparoscopy may be localized pain resulting from incision due to many (two or three) punctures (somatic pain) or due to manipulation of the intra-abdominal organs as ovaries, uterus, omentum, and intestine (visceral pain) or shoulder and back pain caused by retained CO2 in the peritoneal cavity with its irritation effect on the diaphragm.Patients will be divided into two groups:

Intraperitoneal (IP) group (20 patients):They will receive 100 ml normal saline infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline intraoperatively then intraperitoneal wash of 100 ml normal saline containing 30 mg/kg MgSO4 at the end of laparoscopy.

Intravenous (IV) group (20 patients):They will receive 100 ml normal saline containing MgSO4 30 mg/kg infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline containing MgSO4 (8mg/kg) intraoperatively then intraperitoneal wash using 100 ml normal saline at the end of laparoscopy

Enrollment: 44 estimated patients

Sex: Female

Ages: 20 to 44 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

20-44 years old females, (ASA) class I-II

Exclusion criteria

• Patient refusal
• Allergy to MgSO4
• Atrio-ventricular conduction abnormalities
• Drug abuse
• Renal or hepatic or cardiovascular dysfunction
• Prior long-term treatment with calcium channel blockers or magnesium

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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44 participants in 2 patient groups

Intraperitoneal magnesium sulfate (IP) group

Active Comparator group

Description:

They will receive 100 ml normal saline infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline intraoperatively then an intraperitoneal wash of 100 ml normal saline containing 30 mg/kg MgSO4 at the end of laparoscopy.

Treatment:

Drug: intraperitoneal Magnesium sulfate

Intravenous magnesium sulfate (IV) group

Active Comparator group

Description:

They will receive 100 ml normal saline containing MgSO4 30 mg/kg infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline containing MgSO4 (8mg/kg) intraoperatively then intraperitoneal wash using 100 ml normal saline at the end of laparoscopy.

Treatment:

Drug: intravenous magnesium sulfate