Pain After Lung Cancer Surgery - Comparing Traditional Versus Prolonged Release Nerve Blockades

Jannie Bisgaard Stæhr

Status and phase: Unknown; Phase 2

Conditions: Postoperative Pain; Blockades Neuromuscular; Anesthesia, Local; Lung Cancer; Video Assisted Thoracoscopic Surgery

Treatments: Drug: Liposomal bupivacaine; Drug: Bupivacaine Hydrochloride

Study type: Interventional

Funder types: Other

Identifiers

NCT05038007

AAUH-VATS-01

Details and patient eligibility

About

To investigate the effect of liposomal bupivacaine compared with bupivacaine hydrochloride for intercostal blockades for patients undergoing Video-assisted thoracoscopic surgery.

Full description

Video-assisted thoracoscopic surgery (VATS) is a minimally invasive routine procedure. It's less invasive than thoracotomy but postoperative pain is still a problem.

At Aalborg University Hospital, intercostal blockades with bupivacaine is used as standard pain treatment for patients undergoing VATS. Adding adjuvants to the blockades may prolong the effect.

The aim of this study is to examine if intercostal nerve blockades with liposomal bupivacaine improves postoperative pain management compared to intercostal nerve blockades with bupivacaine hydrochloride.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults independent of sex with an age of ≥ 18 years
• Patients undergoing VATS as a part of either examination or treatment of lung cancer

Exclusion criteria

• Patients who are unable to understand oral and written information.
• Patients with known chronic pain in the thorax which have been persisting for at least six months before the day of surgery.
• Pregnant and nursing women.
• Patients with hypersensitivity / allergy / Intolerance to dexamethasone or bupivacaine.
• Patients receiving a planned preoperative epidural blockade during their stay.
• Patients converted to open surgery.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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50 participants in 2 patient groups

Control

Active Comparator group

Description:

Bupivacaine Hydrochloride in perioperative intercostal blockades

Treatment:

Drug: Bupivacaine Hydrochloride

Intervention

Experimental group

Description:

Liposomal bupivacaine in perioperative intercostal blockades

Treatment:

Drug: Liposomal bupivacaine