Pain and Schizophrenia

University Hospital, Strasbourg, France

Status: Terminated

Conditions: Schizophrenia; Pain

Treatments: Other: unpleasant stimuli

Study type: Interventional

Funder types: Other

Identifiers

NCT01244542

4706

Details and patient eligibility

About

The aim of the investigators project is to explore the mechanisms of pain insensitivity in patients with schizophrenia, in order to prevent its invalidating consequences. The investigators will couple methods of experimental psychology with EEG and blood samplings, in order to distinguish the role of non-painful perception, attention, aversive effects, and pain expression, and the investigators will explore an original neurobiological hypothesis regarding the activation of opioid receptors.

Enrollment: 83 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with schizophrenia (criteria DSM IV) or healthy controls matched with patients on age, sex and education level
• 18-55 years old

Exclusion criteria

• Past history affecting CNS
• Intake of psychotropic drugs, except for patients
• Metabolic disorder affecting sensory processing (diabetes)
• Intake of benzodiazepines

Trial design

Primary purpose: Health Services Research

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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83 participants in 2 patient groups

Patients with schizophrenia

Experimental group

Treatment:

Other: unpleasant stimuli

Healthy controls

Active Comparator group

Description:

controls matched with patients on age, sex and education level

Treatment:

Other: unpleasant stimuli