Pain and Stress Assessment and ROP Screening

Loma Linda University (LLU)

Status: Completed

Conditions: Pain; Stress

Study type: Observational

Funder types: Other

Identifiers

NCT02415205

5150005

Details and patient eligibility

About

The study will measure the effects of eye exams on markers of stress in the urine. In addition, measurements will be taken to show the effects of stress on brain activity, O2 sats, and blood flow.

Enrollment: 42 patients

Sex: All

Ages: 24 to 32 weeks old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Premature infants between 24 -32 weeks of gestational age

Exclusion criteria

• Infants scheduled for laser eye surgery on the day of the examination
• Infants with intraventricular hemorrhage ≥ grade 3 (Papile classification) diagnosed by head ultrasound
• Infants receiving the following medications: morphine, fentanyl, methadone, midazolam, lorazepam, muscle relaxants, phenobarbital, phenytoin, levetiracetam
• Renal injury defined with plasma creatinine > 1.5 mg/dL
• Severe cyanotic congenital heart disease
• Unstable respiratory distress (hypoxemia PaO2 < 50 mm Hg or SpO2 < 90%)