Pain in Juvenile Arthritis

The Washington University

Status: Enrolling

Conditions: Juvenile Idiopathic Arthritis

Treatments: Behavioral: Pressure pain thresholds (measured in kilopascal); Behavioral: Cold pain tolerance (duration in seconds)

Study type: Interventional

Funder types: Other

Identifiers

NCT07217782

202505170

Details and patient eligibility

About

Juvenile idiopathic arthritis (JIA) is the most common rheumatologic disease in children. The main symptoms of JIA, which are often the primary focus of treatment, include joint swelling, stiffness, and tenderness. Additional symptoms can include malaise, fatigue, and pain. However, the exact mechanisms contributing to pain are not yet fully understood. Participants will complete a 2.5-hours study session.

In the study session, psychophysical assessments of thermal and pressure stimuli will be performed. In addition, demographic, social, pubertal maturation, and behavioral and psychological factors will be collected via questionnaires. A saliva sample and/or blood draw may occur for the analysis of various immune factors and sex hormones. If a joint aspiration is done as part of their standard of care, we will request a sample of the synovial fluid for analyses of immune, hormonal and/or genetic factors. Participants will have the option to participate in additional optional follow-up study visits (every 3 months, up to 1 year) and to complete monthly surveys asking about their juvenile arthritis.

Enrollment: 140 estimated patients

Sex: All

Ages: 9 to 17 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age between 9-17
2. Males and females
3. English speakers
4. Able to complete surveys and understand study instructions
5. Juvenile arthritis group: diagnosed or suspected of juvenile arthritis
6. Control group: healthy

Exclusion criteria

1. Pregnancy or breastfeeding
2. (Control Group) Diagnosed with a chronic pain condition
3. (Control Group) Diagnosed with psychiatric condition including ADHD, anxiety, depression, etc.

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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140 participants in 2 patient groups

JIA

Other group

Description:

Inclusion: 1. Age between 9-17 2. Males and females 3. English speakers 4. Able to complete surveys and understand study instructions 5. Diagnosed or suspected of juvenile arthritis Exclusion Criteria Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion: 1. Pregnancy or breastfeeding 2. (Control Group) Diagnosed with a chronic pain condition 3. (Control Group) Diagnosed with psychiatric condition including ADHD, anxiety, depression, etc.

Treatment:

Behavioral: Cold pain tolerance (duration in seconds)

Behavioral: Pressure pain thresholds (measured in kilopascal)

Controls

Other group

Description:

Inclusion: 1. Age between 9-17 2. Males and females 3. English speakers 4. Able to complete surveys and understand study instructions 5. Healthy Exclusion Criteria Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion: 1. Pregnancy or breastfeeding 2. (Control Group) Diagnosed with a chronic pain condition 3. (Control Group) Diagnosed with psychiatric condition including ADHD, anxiety, depression, etc.

Treatment:

Behavioral: Cold pain tolerance (duration in seconds)

Behavioral: Pressure pain thresholds (measured in kilopascal)