Pain, Inflammation and Opioid Craving

Mass General Brigham

Status: Completed

Conditions: Opioid-use Disorder

Treatments: Behavioral: Pain De-Catastrophizing; Behavioral: Pain Education

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04190563

R01DA045632 (U.S. NIH Grant/Contract)

2019P002720

Details and patient eligibility

About

The goal of this study is to investigate the association between response to pain and opioid craving in people with opioid use disorder. In this study, adults with opioid use disorder will be randomized to one of two brief education sessions followed by an assessment of response to pain. Investigators will test the association between response to pain and opioid craving.

Enrollment: 89 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18 years or older;
• diagnosis of opioid use disorder
• chronic pain
• ability to read and provide informed consent

Exclusion criteria

• major psychiatric or medical condition that would interfere with participation
• current opioid withdrawal
• currently receiving opioid analgesic medication for pain
• recent history of myocardial infarction or other serious cardiovascular condition
• current peripheral neuropathy, active vasculitis or severe peripheral vascular disease
• systematic inflammatory or autoimmune disorder
• admitted to current treatment episode on an involuntary status

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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89 participants in 2 patient groups, including a placebo group

Pain De-Catastrophizing

Experimental group

Description:

Brief behavioral education on how to modify the interpretation of pain.

Treatment:

Behavioral: Pain De-Catastrophizing

Pain Education

Placebo Comparator group

Description:

Brief behavioral education on pain.

Treatment:

Behavioral: Pain Education