Pain Management After Adductor Canal Block for Total Knee Arthroplasty

Poznan University of Medical Sciences (PUMS)

Status and phase: Completed; Phase 4

Conditions: Knee Arthritis; Knee Pain Chronic; Knee Osteoarthritis; Knee Arthropathy

Treatments: Drug: Ropivacaine 0.2% Injectable Solution; Drug: 0.9%sodium chloride

Study type: Interventional

Funder types: Other

Identifiers

NCT06086483

495/2020

Details and patient eligibility

About

This randomized, double-blinded, placebo-controlled trial sought to evaluate the efficacy of the iPACK block with Adductor Canal Block on postoperative pain, functional recovery and NLR and PLR levels.

Full description

The Interspace between the popliteal artery and capsule of the posterior knee, or iPACK block, together with the Adductor Canal block (ACB), has been described and shows promise in providing analgesia to the knee joint. However, the effect of these two blocks on postoperative pain levels, functional recovery, and stress response is uncertain. This study compares a preoperative iPACK and ACB block to Sham blocks before total knee arthroplasty under spinal anesthesia.

Enrollment: 361 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients > 18 years old undergoing unilateral total knee arthroplasty

Exclusion criteria

• refusal to participate
• < 18 yo
• Chronic opioid use
• localized infection

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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361 participants in 2 patient groups

iPACK block+ABC block

Active Comparator group

Description:

Patients received a preoperative ultrasound-guided iPACK block with 20 mL of 0.25% ropivacaine and an Adductor Canal block with 20mL 0.25% ropivacaine.

Treatment:

Drug: Ropivacaine 0.2% Injectable Solution

Sham blocks

Active Comparator group

Description:

Patients received a preoperative ultrasound-guided iPACK block with 20 mL of 0.9% normal saline and an Adductor Canal block with 20mL 0.9% normal saline.

Treatment:

Drug: 0.9%sodium chloride