Pain Mechanisms in Patients With Bronchiectasis

Universidad San Jorge

Status: Withdrawn

Conditions: Bronchiectasis; Respiratory Disease

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT03376204

PI17/0290

Details and patient eligibility

About

Pain mechanisms and their clinical impact in patients with bronchiectasis have not been investigated yet. The aim of the research is to assess the presence of central pain mechanisms in patients with bronchiectasis using the Quantitative Sensory Testing (QST) assumptions.

Full description

Background and objective:

Recent findings suggest that pain can play an important role in terms of physical activity limitation in respiratory patients. Nevertheless, pain mechanisms and their clinical impact in patients with bronchiectasis have not been investigated yet. The objective of the observational study is to determine the somatosensorial profile in order to assess the presence of central pain mechanisms in patients with bronchiectasis.

Methodology:

Repeated-measures prospective cross-sectional study. A sample of patients diagnosed with bronchiectasis will be recruited and matched by age and sex with healthy controls. Pressure pain thresholds (PPTs), conditioned pain modulation (CPM) and referral pain will be assessed before and after the Incremental Shuttle Walking test (ISW). Levels of physical activity will be assessed using accelerometry during a 7-days period. Sleep quality (Pittsburgh sleep quality test), level of catastrophizing (Pain Catastrophizing Scale), level of sensitization (Central Sensitization Inventory) and level of anxiety and depression (Hospital Anxiety and Depression) will be assessed. The assessments will be done twice: 1) at baseline; and 2) at 6 months follow-up period.

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Bronchiectasis Group

Inclusion Criteria:

• Diagnosis of bronchiectasis by high-resolution computed tomography.
• Ability to understand and perform all the clinical procedure.
• Acquisition of informed consent.

Exclusion Criteria:

• Diagnosis or clinical suspicion of cystic fibrosis by genetic test or sweat electrolytes test.
• Diagnosis of rheumatic disease.
• Being on a waiting list for lung transplantation.
• Thoraco-abdominal surgery in the last 6 months.
• Chronic use of pain medication.

Control Group

Inclusion Criteria:

• Healthy subjects matched by age and sex with Bronchiectasis Group's subjects

Exclusion Criteria:

• Be taking pain medication.
• Presence of pain condition or pathology.

Trial design

0 participants in 1 patient group

Adult subjets

Description:

Adult subjets diagnosed with bronchiectasis by high-resolution computed tomography with symptomatology in stable phase, matched by by sex and age with healthy subjects.

Treatment:

Other: No intervention