Pain Phenotype in Patients With Carpal Tunnel Syndrome

Kutahya Health Sciences University

Status: Completed

Conditions: Carpal Tunnel Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT06635200

2024

Details and patient eligibility

About

The aim of this study was to determine the dominant pain phenotype in a group of patients with Carpal Tunnel Syndrome by applying the International Association for the Study of Pain (IASP) criteria.

Full description

Voluntary participants between the ages of 18-65 who have been diagnosed with CTS will be included in the study.The 7 steps in the Clinical Criteria/Rating System determined by the International Association for the Study of Pain (IASP) for Nosiplastic Pain and Carpal Tunnel Syndrome will be applied to people with CTS. Thermal pain threshold, mechanical pain sensitivity and static/dynamic allodynia will be evaluated to determine pain hypersensitivity (Step 5). Specific questions will be asked to confirm the history of hypersensitivity in patients (Step 6). Finally, comorbidities, if any, will be determined (Step 7). As a result, the pain phenotype of patients with CTS will be determined (Nociceptive, Neuropathic or Nosiplastic). Shapiro-Wilk test will be performed to determine the distribution of the data. One-way ANOVA (continuous) or Kruskal-Wallis (categorical) will be used to examine whether the dependent variables differ between groups. For significant F-test, an additional investigation of differences between groups will be performed with Gabriel's post hoc procedure.

Enrollment: 113 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Being diagnosed with CTS
• Being between the ages of 18-65
• Volunteering to participate in the study

Exclusion criteria

• Having systemic inflammatory disease
• Having a disease that may cause polyneuropathy such as diabetes mellitus
• Having a pacemaker
• Having a disease affecting the central nervous system
• Having cervical radiculopathy
• History of previous operation or local steroid injection due to CTS
• Hypersensitivity to heat and cold

Trial design

113 participants in 3 patient groups

Patients with carpal tunnel syndrome with a nociceptive pain phenotype

Patients with carpal tunnel syndrome with a neuropathic pain phenotype

Patients with carpal tunnel syndrome with a nosiplastic pain phenotype