Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

University of Florida

Status: Enrolling

Conditions: Fibromyalgia; Rheumatoid Arthritis

Study type: Observational

Funder types: Other

Identifiers

NCT05277025

IRB202200105

Details and patient eligibility

About

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ages 18-70
• Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
• Fulfills the 2010 ACR-EULAR classification criteria for RA
• Healthy volunteers: No significant pain/fatigue/depression/anxiety.

Exclusion criteria

• Diabetes
• Cancer
• Advanced liver, kidney or cardiovascular disease
• Neuropathic pain

Trial design

150 participants in 3 patient groups

Fibromyalgia

Description:

Participants who fulfill the 1990 and 2011 American College of Rheumatology Criteria for FM.

Rheumatoid Arthritis

Description:

Participants who fulfill the 2010 American College of Rheumatology (ACR)-European League against rheumatism (EULAR) classification criteria for RA.

Healthy Volunteers

Description:

Participants who do not have significant pain/fatigue/anxiety/depression.