Ibuprofen and Neural Mobilization Treatment in Carpal Tunnel Syndrome.

European University

Status and phase: Completed; Phase 4

Conditions: Ibuprofen; Pain Management; Carpal Tunnel Syndrome; Pain, Chronic

Treatments: Other: Median nerve neural mobilization; Drug: ibuprofen tablets

Study type: Interventional

Funder types: Other

Identifiers

NCT04328805

CE0072015-02-05

Details and patient eligibility

About

In the present investigation, the pain reduction effect of median nerve neural mobilization and oral ibuprofen treatments will be compared to those produced by the absence of treatment, in subjects who suffer the signs and symptoms of carpal tunnel syndrome.

Full description

The present randomized clinical trial will perform a comparison of the pain reduction effects produced by median nerve neural mobilization and oral ibuprofen treatments to the total lack of treatment in subjects diagnosed with carpal tunnel syndrome. Effects over the functionality of the affected upper limb will be evaluated and compared. Subjects will be invited to participate and randomly allocated to 3 different groups.

Enrollment: 42 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants must be medically diagnosed with unilateral carpal tunnel syndrome (with confirmative electrodiagnostic findings).
• Full understanding of written and spoken Spanish (language).
• Participants must freely consent to participate.
• The presence of positive Phalen and Tinel signs.
• The presence of carpal tunnel syndrome signs and symptoms.

Exclusion criteria

• The lack to meet inclusion criterions,
• The presence of cognitive impairment,
• Tumors
• Cancer
• Upper limb surgery or trauma
• Pregnancy
• Deformities of the (affected) upper limb,
• Recent skin injuries or infections (in the affected upper limb)
• Autoimmune inflammatory conditions or flu type symptoms
• Allergy (or contraindication) to non steroidal anti inflammatory drugs (NSAID)
• Participants must not be (during the present investigation) under any type of pain reducing treatment (conservative, homeopathic, invasive or not invasive).

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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42 participants in 3 patient groups

Ibuprofen

Active Comparator group

Description:

Oral tablet pharmaceutical treatment. Participants will be treated with a maximum of 1200 mg per day, subdivided in 3 intakes of 400 mg each 8 hours during a time lapse of 4 weeks.

Treatment:

Drug: ibuprofen tablets

Control group

No Intervention group

Description:

Waiting list control group. Participants that belong to the no intervention arm will be assigned to a waiting list to receive treatment. The participants will not receive treatment for carpal tunnel syndrome during a time lapse of 4 weeks. After this period of time, participants will begin the best treatment available.

Median nerve neural mobilization

Experimental group

Description:

Median nerve neural mobilization non pharmaceutical, non invasive, physiotherapy technique; which consists of a passive and repetitive upper limb movement that seeks to induced median nerve gliding and incursions against surrounding connective tissue. Subjects will be treated 5 days per week during a total time lapse of 4 weeks.

Treatment:

Other: Median nerve neural mobilization