Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients

Mahidol University

Status: Terminated

Conditions: Corneal Ulcer

Treatments: Procedure: NSS/Lidocaine; Procedure: Lidocaine/NSS

Study type: Interventional

Funder types: Other

Identifiers

NCT00789646

SI 271/2008

Details and patient eligibility

About

The propose of this study is to determine the efficacy of 2% xylocaine in reducing pain due to subconjunctival antibiotic and antifungal injection.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The corneal ulcer patients who are diagnosed by ophthalmologist and have 2 of 3 in these following features.

  1. corneal epithelial defect with stromal infiltration
  2. reaction in anterior chamber
  3. positive for bacteria or fungus

• The patients have to receive subconjunctival antibiotic injection twice at least.

• The patients must be informed consent.

Exclusion criteria

• The patients who have history of allergy of local anesthetics, antibiotics or antifungal drugs.
• The patients who administered NSAIDs or weak opioids within 24 hours prior to subconjunctival antibiotic/antifungal injection.
• Unable to cooperate with the treatment.
• Pregnant women

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

---

10 participants in 2 patient groups

NSS/Lidocaine

Experimental group

Description:

First injection: Normal saline Second injection: 2% Lidocaine without adrenaline

Treatment:

Procedure: NSS/Lidocaine

Lidocaine/NSS

Experimental group

Description:

First injection: 2% Lidocaine without adrenaline Second injection: Normal saline

Treatment:

Procedure: Lidocaine/NSS