Paired Acute Invasive/Non-invasive Stimulation Trial (PAINS)

University of Oxford

Status: Completed

Conditions: Chronic Pain

Treatments: Device: Transcranial direct current stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03954093

13/SC/0298

Details and patient eligibility

About

Chronic pain patients with implanted dorsal root ganglion stimulators will be randomized to receive transcranial direct current stimulation (tDCS) to the motor cortex, magneto-encephalographically (MEG) localized stimulation or sham stimulation to identify therapeutic efficacy of paired central and peripheral neuromodulation.

Enrollment: 16 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients who are willing and able to give consent to the study.
• Male or Female, aged 18 years or above with diagnoses of chronic pain.
• Treatment includes Spinal Cord Stimulation, Dorsal Root Ganglion stimulation, or peripheral analgesic stimulation.

Exclusion criteria

• Patients who do not wish to be in the study.
• Patients with metallic intracranial implants.
• Patients with extreme language barrier that cannot understand the purpose of the study despite the use of an interpreter

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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16 participants in 3 patient groups

Sham stimulation

Sham Comparator group

Treatment:

Device: Transcranial direct current stimulation

Motor cortex stimulation

Active Comparator group

Treatment:

Device: Transcranial direct current stimulation

MEG-localized stimulation

Experimental group

Treatment:

Device: Transcranial direct current stimulation