Paired Associative Stimulation in Methamphetamine Addiction

Shanghai Mental Health Center

Status: Unknown

Conditions: Methamphetamine-dependence

Treatments: Device: MagPro X100 device (MagVenture, Farum, Denmark)

Study type: Interventional

Funder types: Other

Identifiers

NCT03910608

HFJiang-003

Details and patient eligibility

About

The investigators use paired associative stimulation (PAS) protocols to target cortico-cortical and cortico-subcortical networks to study cognitive deficits in methamphetamine addiction.

Full description

Paired associative stimulation (PAS) is a form of transcranial magnetic stimulation in which paired pulses can induce plasticity at cortical synapses, producing long-term potentiation (LTP) or long-term depression (LTD) effect. The investigators use paired associative stimulation (PAS) protocols to target cortico-cortical and cortico-subcortical networks (frontoparietal control pathway) by using different intervals between the paired pulses to explore the mechanism of cognitive deficits in methamphetamine addiction. The investigators hypothesize that different temporal sequences of cortical stimulation could produce facilitation or inhibition effect.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• In accordance with the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) for methamphetamine (MA) use disorders
• Junior high school degree or above
• Normal vision and hearing
• Dextromanual

Exclusion criteria

• Have a disease that affect cognitive function such as history of head injury, cerebrovascular disease, epilepsy, etc
• Have cognitive-promoting drugs in the last 6 months
• Other substance abuse or dependence in recent five years (except nicotine)
• Mental impairment, Intelligence Quotient (IQ) < 70
• Mental disorders
• Physical disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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90 participants in 8 patient groups

DLPFC+10 IPL

Experimental group

Description:

Stimulation of dorsolateral prefrontal cortex (DLPFC) 10 ms before inferior parietal lobule (IPL) presumes that the DLPFC to IPL input facilitates insula postsynaptic output activity, thereby improving cognition response via a long term potentiation-like effect.

Treatment:

Device: MagPro X100 device (MagVenture, Farum, Denmark)

IPL+10 DLPFC

Experimental group

Description:

Stimulation of IPL 10 ms before DLPFC presumes that the IPL to DLPFC input inhibits insula postsynaptic output activity, thereby impairing cognition response via a long term depression-like effect.

Treatment:

Device: MagPro X100 device (MagVenture, Farum, Denmark)

IPL+4 DPLFC

Experimental group

Description:

Stimulation of IPL 4 ms before DLPFC is presumed to be too brief for a corticocortical effect but presumes that the DLPFC input to insula inhibits insula postsynaptic output by weakening the IPL to insula input, thereby impairing cognition response.

Treatment:

Device: MagPro X100 device (MagVenture, Farum, Denmark)

DLPFC+4 IPL

Experimental group

Description:

Stimulation of DLPFC 4 ms before IPL is presumed to be too brief for a corticocortical effect but presumes that the DLPFC input to insula potentiates insula postsynaptic output by strengthening the IPL to insula input, thereby improving cognition response.

Treatment:

Device: MagPro X100 device (MagVenture, Farum, Denmark)

DLPFC+4 MPFC

Experimental group

Description:

Stimulation of DLPFC 4 ms before medial prefrontal cortex (MPFC) presumes that the DLPFC input facilitates MPFC postsynaptic output activity, thereby improving cognition response via a long term potentiation-like effect.

Treatment:

Device: MagPro X100 device (MagVenture, Farum, Denmark)

MPFC+4 DLPFC

Experimental group

Description:

Stimulation of MPFC 4 ms before DLPFC presumes that the DLPFC input inhibits MPFC postsynaptic output activity, thereby impairing cognition response via a long term depression-like effect.

Treatment:

Device: MagPro X100 device (MagVenture, Farum, Denmark)

DLPFC+10 MPFC

Experimental group

Description:

Stimulation of DLPFC 10 ms before medial prefrontal cortex (MPFC) presumes that the DLPFC input facilitates MPFC postsynaptic output activity, thereby improving cognition response via a long term potentiation-like effect.

Treatment:

Device: MagPro X100 device (MagVenture, Farum, Denmark)

MPFC+10 DLPFC

Experimental group

Description:

Stimulation of MPFC 10 ms before DLPFC presumes that the DLPFC input inhibits MPFC postsynaptic output activity, thereby impairing cognition response via a long term depression-like effect.

Treatment:

Device: MagPro X100 device (MagVenture, Farum, Denmark)