Palliation of Dyspnea With Mouth Piece Ventilation in AECOPD

Tampere University Hospital

Status: Terminated

Conditions: Dyspnea; COPD Exacerbation

Treatments: Device: Trilogy 100 ® (Philips Respironics)

Study type: Interventional

Funder types: Other

Identifiers

NCT03025425

R16148_TAYS

Details and patient eligibility

About

An uncontrolled feasibility study on using mouth piece ventilation in palliation of dyspnea in subjects with acute exacerbation of COPD without acute hypercapnic respiratory failure. Subjects are recruited from the local respiratory ward. The main outcomes are the compliance of the subjects with the treatment and alleviation of dyspnea during the treatment period.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• a previous diagnosis of COPD
• hospitalized due to acute exacerbation of COPD
• at least moderate dyspnea (NRS = Numeric Rating Scale ≥ 4)
• no acute hypoventilation (pH ≥ 7.35 and PCO2 ≤ 6.0 kPa)
• able to understand the study and to give informed consent

Exclusion criteria

• unable to participate and use MPV due to e.g. delirium or lack of co-operation
• acute hypoventilation (pH < 7.35 or PCO2 > 6.0 kPa)
• acute need for ventilatory support
• the cause of the dyspnea can be successfully treated
• unable to give informed consent
• a previous chronic hypoxemic or hypercapnic respiratory insufficiency that has been treated on a long-term basis also at home

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

MPV-arm

Experimental group

Description:

Subjects use mouth piece ventilation (MPV) according to their will for 24 hours to alleviate dyspnea.

Treatment:

Device: Trilogy 100 ® (Philips Respironics)