Palmitic Acid in the Sn-2 Position of Triacylglycerols and Postprandial Lipemia

King's College London

Status

Completed

Conditions

Raised Fasting Plasma Triacylglycerol Concentrations

Healthy Men

Treatments

Dietary Supplement: High-fat meal containing native palm olein

Dietary Supplement: High-fat meal containing interesterified palm olein

Study type

Interventional

Funder types

Other

Identifiers

NCT01710280

IRIS

Details and patient eligibility

About

The purpose of this study is to determine whether high-fat meals rich in palmitic acid in the sn-2 position decrease lipaemia in men aged 40-70 y with higher than optimal fasting triacylglycerol concentrations.

Enrollment

11 patients

Sex

Male

Ages

40 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy males
Non-smokers
Aged 40-70 years
Fasting TAG concentrations ≥1.5 mmol/L.

Exclusion criteria

Reported history of CVD (myocardial infarction, angina, venous thrombosis, stroke), impaired fasting glucose/uncontrolled type 2 diabetes (or fasting glucose ≥ 6.1 mmol/L), cancer, kidney, liver or bowel disease.
Presence of gastrointestinal disorder or use of drug, which is likely to alter gastrointestinal motility or nutrient absorption.
History of substance abuse or alcoholism (previous weekly alcohol intake >60 units/men)
Current self-reported weekly alcohol intake exceeding 28 units
Allergy or intolerance to any component of test meals
Unwilling to restrict consumption of any source of fish oil for the length of the study
Weight change of >3kg in preceding 2 months
Body Mass Index <20 and >35 kg/m2
Fasting blood cholesterol > 7.8 mmol/L
Current cigarette smoker.
Current use of lipid lowering medication