Pancreatic Exocrine Insufficiency After Bariatric Surgery

Umraniye Education and Research Hospital

Status: Unknown

Conditions: Pancreatic Insufficiency; Obesity, Morbid

Treatments: Procedure: SleeveGastrectomy

Study type: Observational

Funder types: Other

Identifiers

NCT03279653

p-exocrine-insufficiency

Details and patient eligibility

About

Main proposed benefit of sleeve gastrectomy is loss of ghrelin secreting tissue. Some studies express that ghrelin augment pancreatic regeneration. Therefore we hypothesized that with sleeve gastrectomy it may result with pancreatic insufficiency.

Full description

Mechanism of weight loss differs in bariatric surgery according to type of surgery.

With sleeve gastrectomy which has restrictive mechanism, ghrelin excretion decreases, and this condition is attributed as an additional mechanism in weight loss.

Ghrelin effects pancreatic regeneration, and loss of ghrelin may result with pancreatic insufficiency. Therefore we aimed to deteremine this association.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients underwent bariatric surgery (Sleeve gastrectomy) after concordonce with NIH criteria

Exclusion criteria

Additional operations to sleeve gastrectomy like duodenal switch. Other bariatric operations.

Trial design

50 participants in 1 patient group

SleeveGastrectomy

Description:

Sleeve Gastrectomy will be performed. Preoperative and Postoperative pancreatic enzyme sufficiency (with steatocrit or fecal elastase) will be compared.

Treatment:

Procedure: SleeveGastrectomy