Pancreaticogastrostomy for High-Risk Pancreas (GASTROPAN)

Institut Paoli-Calmettes

Status: Completed

Conditions: Pancreatic Fistula; Anastomosis; Complications

Treatments: Procedure: pancreaticojejunostomy; Procedure: pancreaticogastrostomy

Study type: Observational

Funder types: Other

Identifiers

NCT04724174

GASTROPAN IPC-2020-029

Details and patient eligibility

About

In 2013, a double purse-string telescoped pancreaticogastrostomy (PG) technique appeared to significantly reduce the risk of postoperative pancreatic fistula (POPF). This study compared the incidence of clinically relevant POPF in patients with high-risk anastomosis after undergoing PG or pancreaticojejunostomy (PJ) techniques.

Full description

From 2013 to 2019, consecutive patients with high-risk anastomosis (i.e., updated alternative-Fistula Risk Score (ua-FRS) >20%) underwent pancreatoduodenectomy with either the PJ or PG technique. Optimal mitigation strategy (external stenting and octreotide omission) was applied for all patients. The primary endpoint of the study was the incidence of clinically relevant POPF. Data were entered prospectively into an institutional clinical database (NCT02871336).

Enrollment: 198 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pancreatoduodenectomy
• High updated alternative -Fistula Risk Score which was defined > 20%, as the higher-risk category of the alternative-Fistula Risk Score

Exclusion criteria

• Explorative laparotomy
• Hard pancreatic parenchyma

Trial design

198 participants in 2 patient groups

Pancreaticogastrostomy (PG) group

Description:

Patients underwent pancreatoduodenectomy with the PG technique

Treatment:

Procedure: pancreaticogastrostomy

Pancreaticojejunostomy (PJ) group

Description:

Patients underwent pancreatoduodenectomy with the PJ technique

Treatment:

Procedure: pancreaticojejunostomy