Pangenomic Study During Alcoholic Cirrhosis (CDCHC)

Nantes University Hospital (NUH)

Status: Completed

Conditions: Alcoholic Cirrhosis

Treatments: Genetic: DNA extraction

Study type: Observational

Funder types: Other

Identifiers

NCT01065233

BRD/07/08-M

Details and patient eligibility

About

Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome.

The determining of a genomic mapping of " single nucleotide polymorphisms " (SNPs) permit to perform some genetic link studies with pathologies without clear hereditary disposition.

In this study, the investigators will identify predictives genetic polymorphism of HCC.

Enrollment: 1,325 patients

Sex: All

Ages: 35 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 35 to 70 years old
• Compensated cirrhosis or not
• Caucasian origin of the parents
• Patient with cirrhosis (histological proof or obvious)

Exclusion criteria

• HIV, HBV, HCV positive
• Known Homozygotia (C282Y+/+)
• Important hepatocytary iron overload for patient with resection
• HCC non histologically prooved

Trial design

1,325 participants in 2 patient groups

alcoholic cirrhosis with viral infection

Description:

patient with alcoholic cirrhosis with viral infection (300 patients)

Treatment:

Genetic: DNA extraction

alcoholic cirrhosis without viral infection

Description:

patient with alcoholic cirrhosis without viral infection

Treatment:

Genetic: DNA extraction