PaO2/FiO2*PEEP (P/FP) Ratio and Mortality in Acute Respiratory Distress Syndrome.

National University Health System, Singapore

Status: Completed

Conditions: Adult Respiratory Distress Syndrome

Treatments: Diagnostic Test: P/FP Ratio

Study type: Observational

Funder types: Other

Identifiers

NCT03946150

NUHSSingapore

Details and patient eligibility

About

The PaO2/FiO2 (P/F) ratio is same for all the Positive End Expiratory Pressure (PEEP) ≥ to 5. This P/F ratio misleads the severity of disease without the knowledge of set PEEP. The Oxygenation status is actually worse when the patient is using high PEEP.

P/F Ratio doesn't include PEEP in the calculation.The P/F ratio doesn't show the severity of the disease appropriate for the set PEEP.

PaO2/(FiO2 X PEEP) P/FP Ratio is a new Formula which addresses this gap to appropriately calculate the severity of the disease by including PEEP in the formula.

This formula is used to predict mortality for different severities of ARDS.

Full description

The Main aim of this study is to analyse whether this formula can early diagnose the severity of the disease appropriate for the set PEEP, so the Rescue measure can be started early which can eventually decreases the mortality.

Increasing the PEEP Value with the same Fio2 gives a different PaO2 and SpO2. The oxygenation improves substantially by increasing only the PEEP. So including the PEEP in calculating the severity of Oxygenation is better than the current practice.

The current Definition of ARDS for Oxygenation is P/F Ratio of 300 to 200 is Mild, 200 to 100 is Moderate and less than 100 is Severe ARDS with PEEP ≥ 5.

The New P/FP Ratio of 300 to 200 is mild, 200 to 100 is moderate and less than 100 is severe Adult Respiratory Distress Syndrome (ARDS) for all the different levels of PEEP values.

Enrollment: 4,361 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Intubated patients for

• Adult Respiratory Distress Syndrome
• Stroke
• Seizures
• Post neurosurgery
• Endoscopy Procedure
• Post Cardiac Collapse

Exclusion Criteria

Non intubated patients on

• Room Air
• Nasal Cannula
• Face mask
• Venturi Mask
• Non Rebreathing mask

Trial design

4,361 participants in 2 patient groups

P/FP Ratio

Description:

P/FP Ratio is calculated in ARDS Patients retrospectively and analyse whether this new formula with PEEP can appropriately diagnose the Severity of Oxygenation with different levels of PEEP.

Treatment:

Diagnostic Test: P/FP Ratio

P/F ratio

Description:

P/F ratio is the current Berlin definition of ARDS in Calculating the severity of Oxygenation.

Treatment:

Diagnostic Test: P/FP Ratio