Paracetamol Effect on Prostaglandins and Blood Pressure (PIS-PaB)

Charité University Medicine Berlin

Status

Not yet enrolling

Conditions

Pain

Treatments

Other: routine clinical treatment of pain with paracetamol or ibuprofen

Study type

Observational

Funder types

Other

Identifiers

NCT06235320

PIS-PaB

Details and patient eligibility

About

This research program aims to investigate the influence of paracetamol on blood pressure and the cyclooxygenase (COX) - prostaglandine (PG) pathway in patients with pain. Through an observational pilot study, we will use advanced LC/ESI-MS/MS methodology to analyze the COX-OG pathway in plasma and urine. The study will assess the effects of paracetamol compared to ibuprofen, considering different types of pain. The primary focus is to understand the changes in blood pressure and the COX-PG pathway upon initiation or discontinuation of paracetamol, with safety analysis as a secondary consideration.

Enrollment

72 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Headache and orosurgical patients treated at the respective charite outpatient clinic.
Age 18 years or older
Able to consent
Patients with migraine type headache treated with paracetamol or ibuprofen within the last 12 hours or not treated with paracetamol or ibuprofen within the last 48 hours
Patients treated with with paracetamol or ibuprofen undergoing orosurgery for wisedome tooth extraction

Exclusion criteria

Pregnancy
Arterial hypertension
Use of beta blockers
Use of COX inhibitors other than paracetamol or ibuprofen, including low-dose acetylsalicylic acid
Stable prophylactic therapy of migraine for less than 3 weeks
Use of tryptans in the last two days (Frovatriptane in the last 6 days)
Oral surgery patients using paracetamol or ibuprofen in the last 24 hours
Known allergy to paracetamol or ibuprofen