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Parameters of Cerebral Perfusion

U

UMC Utrecht

Status

Completed

Conditions

Cardiopulmonary Bypass
Cerebral Oxygenation
Cerebral Perfusion

Treatments

Other: Increasing CPB flow
Other: Decreasing CPB flow AND 50-100ug phenylephrine
Other: 50-100ug phenylephrine before CPB
Other: 50-100ug phenylephrine during CPB
Other: decreasing CPB flow

Study type

Interventional

Funder types

Other

Identifiers

NCT02806492
NL48417.041.14

Details and patient eligibility

About

The purpose of this study is to determine whether cerebral blood flow and cerebral tissue oxygenation is most dependent on cardiac output or on mean arterial pressure in patients undergoing cardiac surgery with the use of cardiopulmonary bypass.

Enrollment

15 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Undergoing cardiopulmonary bypass for CABG a
  • having an appropriate temporal bone window for reliable TCD monitoring
  • needing pharmacological intervention because of hypotension before going on CPB.

Exclusion criteria

  • requiring hypothermia during surgery
  • requiring emergency surgery
  • contraindication for phenylephrine,
  • having known brain pathology (e.g. Cerebral Vascular Accident (CVA) or increased intracranial pressure
  • having a history of severe carotid artery stenosis.

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

15 participants in 1 patient group

Patient for cardiac surgery
Experimental group
Description:
All patient undergo the 5 different intervention in a randomised matter.
Treatment:
Other: Decreasing CPB flow AND 50-100ug phenylephrine
Other: 50-100ug phenylephrine before CPB
Other: decreasing CPB flow
Other: 50-100ug phenylephrine during CPB
Other: Increasing CPB flow

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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