Parameters of Cerebral Perfusion

UMC Utrecht

Status: Completed

Conditions: Cardiopulmonary Bypass; Cerebral Oxygenation; Cerebral Perfusion

Treatments: Other: Increasing CPB flow; Other: Decreasing CPB flow AND 50-100ug phenylephrine; Other: 50-100ug phenylephrine before CPB; Other: 50-100ug phenylephrine during CPB; Other: decreasing CPB flow

Study type: Interventional

Funder types: Other

Identifiers

NCT02806492

NL48417.041.14

Details and patient eligibility

About

The purpose of this study is to determine whether cerebral blood flow and cerebral tissue oxygenation is most dependent on cardiac output or on mean arterial pressure in patients undergoing cardiac surgery with the use of cardiopulmonary bypass.

Enrollment: 15 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Undergoing cardiopulmonary bypass for CABG a
• having an appropriate temporal bone window for reliable TCD monitoring
• needing pharmacological intervention because of hypotension before going on CPB.

Exclusion criteria

• requiring hypothermia during surgery
• requiring emergency surgery
• contraindication for phenylephrine,
• having known brain pathology (e.g. Cerebral Vascular Accident (CVA) or increased intracranial pressure
• having a history of severe carotid artery stenosis.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

Patient for cardiac surgery

Experimental group

Description:

All patient undergo the 5 different intervention in a randomised matter.

Treatment:

Other: Decreasing CPB flow AND 50-100ug phenylephrine

Other: 50-100ug phenylephrine before CPB

Other: decreasing CPB flow

Other: 50-100ug phenylephrine during CPB

Other: Increasing CPB flow