Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection (SNP)

Civil Hospices of Lyon

Status: Enrolling

Conditions: Paraneoplastic Neurological Syndromes or Autoimmune Encephalitis

Treatments: Biological: Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.

Study type: Interventional

Funder types: Other

Identifiers

NCT05198661

69HCL21_1271

Details and patient eligibility

About

Numerous neurological disorders affecting the central and peripheral nervous system can be attributed to the immune system through multiple effector mechanisms. However, current treatments could be drastically improved by faster and more accurate diagnosis. The sample collection will benefit to patients with rare neuroimmune syndromes such as Autoimmune Encephalitis (AE) and Paraneoplastic Neurological Syndromes (PNS) leading to a better and early diagnosis, as well as treatment improvement.

Enrollment: 3,500 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with consent
• Patient with well-characterized antibodies in serum or cerebrospinal fluid or not
• Patient with neurological disorder compatible with PNS or auto-immune encephalitis

Exclusion criteria

• Refusal of consent
• Patient under guardianship

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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3,500 participants in 1 patient group

Paraneoplastic neurological syndrome patients and autoimmune encephalitis patient

Other group

Description:

patients with diagnosis of paraneoplastic neurological syndrome or autoimmune encephalitis

Treatment:

Biological: Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.