Parasitic Infections and Ulcerative Colitis: Combining Anti-parasitic and Immunomodulatory Treatments May Achieve Remission

Benha University

Status: Completed

Conditions: Ulcerative Colitis

Treatments: Drug: Echinacea Extract; Drug: MetroNIDAZOLE 500 MG Oral Tablet [Flagyl]

Study type: Interventional

Funder types: Other

Identifiers

NCT06583863

RC 16-7-2024

Details and patient eligibility

About

The study aimed to explore the link between parasitic infections and the severity of ulcerative colitis (UC). 120 UC patients were divided into three groups: those without infection, those with Giardia lamblia infection treated with metronidazole, and those with Giardia infection treated with a combination of metronidazole and E. purpurea. The results revealed that patients with Giardia infections exhibited more severe UC symptoms. All groups experienced improved symptoms following treatment, but the combination therapy group demonstrated the most significant improvement. Remission rates were highest in the group without infection and the group receiving combination therapy. Additionally, the study identified E. purpurea therapy and a substantial reduction in SCCAI score as significant predictors of higher remission rates.

Enrollment: 120 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ulcerative Colitis patients had active disease,
• Patients had parasitic infection by G. lambellia,
• Patients free of parasitic infection,
• Patients free of exclusion criteria..

Exclusion criteria

• Patients had Inflammatory Bowel Disease other than Ulcerative Colitis,
• Patients had multiple parasitic infections,
• Patients had infection by parasites other than G. lambellia,
• Patients who were maintained on immunosuppressant therapy,
• Patients who were in remission and patients refused to sign the written consent to participate in the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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120 participants in 3 patient groups

Control Group

Active Comparator group

Treatment:

Drug: Echinacea Extract

Group I

Active Comparator group

Treatment:

Drug: MetroNIDAZOLE 500 MG Oral Tablet [Flagyl]

Group II

Active Comparator group

Treatment:

Drug: MetroNIDAZOLE 500 MG Oral Tablet [Flagyl]

Drug: Echinacea Extract