Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion

Cairo University (CU)

Status: Enrolling

Conditions: Critically Ill

Treatments: Device: Parasternal intercostal thickening fraction; Device: Sham parasternal intercostal thickening

Study type: Interventional

Funder types: Other

Identifiers

NCT07143695

PIC criterion

Details and patient eligibility

About

Increased days of MV are not without hazards, including barotraumas and ventilator-associated pneumonia. Similarly, premature separation of MV is associated with increased mortality secondary to adverse cardiorespiratory events. Therefore, the time of weaning should be wisely evaluated. There is growing evidence concerning respiratory muscles dysfunction that contributes to difficulty or prolonged liberation from MV.

Full description

Researchers aim to evaluate the influence of adding parasternal thickening fraction to the standard weaning criteria and its impact on reintubation

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• critically ill patient mechanically ventilated for 24 hours or more first spontaneous breathing trial

Exclusion criteria

• patient refusal difficult ultrasound views tracheostomized patient neuromuscular disorders

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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200 participants in 2 patient groups

Control group

Sham Comparator group

Description:

patients in control will be weaning using standard criteria

Treatment:

Device: Sham parasternal intercostal thickening

Ultrasound

Active Comparator group

Description:

patient in this group will be weaned using standard criteria plus mean parasternal thickening fraction less than 6.5 %

Treatment:

Device: Parasternal intercostal thickening fraction