Parathyroid Auto-transplantation: Prospective Randomized Trial of the Personalized Site

Tongji Hospital

Status: Unknown

Conditions: Parathyroid Autologous Transplantation

Treatments: Procedure: injection with a syringe in new-site for parathyroid autografting; Procedure: injection with a syringe in traditional site for parathyroid autografting

Study type: Interventional

Funder types: Other

Identifiers

NCT02906748

PA in Tongji Hospital

Details and patient eligibility

About

The functional parathyroid auto-transplantation (PA) could release parathyroid hormone (PTH) into the circulatory system of the body through the capillaries. But when parathyroid glands were auto-grafted in the sternocleidomastoid muscle, it would be inconvenient to detect PTH to examine whether the graft functions. So the investigators took the forearm as the aim place for auto-transplantation, either subcutaneous or brachioradialis, with its relatively fixed - antecubital vein blood test which is simple. The survival criteria is assumed as the PTH gradient of 1.5 times or greater through comparing the bilateral PTH value in grafted and not-grafted forearm.

Enrollment: 280 estimated patients

Sex: All

Ages: 10 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with indications for PA treatment during cervical surgery

Exclusion criteria

• patients suffering secondary hypoparathyroidism with forearm fistulization

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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280 participants in 2 patient groups

new site for parathyroid auto-graft

Experimental group

Description:

choose the site fairly close to the antecubital vein for parathyroid auto-transplantation

Treatment:

Procedure: injection with a syringe in new-site for parathyroid autografting

traditional parathyroid autograft

Active Comparator group

Description:

choose not intensely close to antecubital vein for parathyroid auto-transplantation

Treatment:

Procedure: injection with a syringe in traditional site for parathyroid autografting