Parathyroid Hormone Kinetics During CRRT

Uniwersytecki Szpital Kliniczny w Opolu

Status: Completed

Conditions: Respiratory Failure; Renal Failure; Multi Organ Failure; Critical Illness; Circulatory Failure

Treatments: Diagnostic Test: parathyroid hormone

Study type: Observational

Funder types: Other

Identifiers

NCT03873675

AKIparathormoneCRRTstudy

Details and patient eligibility

About

The objective of this study is to assess the parathyroid hormone serum concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multi-organ failure and undergoing citrate anticoagulation continuous renal replacement therapy.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acute respiratory failure
• Acute circulatory failure
• acute kidney injury treated with regional citrate anticoagulation continuous renal replacement therapy by means of continuous veno-venous hemodiafiltration (CVVHDF
• continuous renal replacement therapy started no later than 48 hours after admission
• SOFA score 5 or more

Exclusion criteria

• age less than 18 years
• acute liver failure
• hypercalcemia at admission (total calcium plasma level > 10.6 mg/dL; total ionized calcium plasma level > 1.35 mmol/L
• parathyroid glands disease
• end stage renal disease
• therapeutic plasma exchange
• extracorporeal membrane oxygenation
• unfavorable outcome (death) predicted within 72 hours (as assessed by investigator)
• lack of relatives consent

Trial design

30 participants in 1 patient group

Study group

Description:

Multi-organ failure with acute kidney injury critically ill patients admitted to the intensive care unit undergoing regional citrate anticoagulation continuous renal replacement therapy by means of continuous veno-venous hemodiafiltration (CVVHDF). Multi-organ failure is defined as a respiratory, circulatory and renal failure.

Treatment:

Diagnostic Test: parathyroid hormone