Parecoxib for Pain Management After Total Knee Arthroplasty and Total Hip Arthroplasty

Chinese Academy of Medical Sciences & Peking Union Medical College

Status and phase: Completed; Phase 4

Conditions: Pain, Postoperative

Treatments: Drug: Parecoxib sodium; Drug: Normal saline injection

Study type: Interventional

Funder types: Other

Identifiers

NCT02272660

S-503

Details and patient eligibility

About

Evaluated the effect of perioperative parecoxib administration on postoperative pain, analgesic use, function recovery, inflammatory response and bleeding risk.

Full description

Non-steroid anti-inflammatory drugs are recommended for multimodal postoperative pain management.

We evaluated the effect of perioperative parecoxib administration on postoperative pain, analgesic use, function recovery, inflammatory response and bleeding risk.

Enrollment: 74 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Male or female patients who have underwent primary unilateral total knee arthroplasty (TKA) and total hip arthroplasty (THA).
2. Age between 18-65 years.
3. Chinese ethnicity.

Exclusion criteria

1. patients who underwent a reversion or a previous TKA or THA, emergency TKA, or TKA as result of a trauma.
2. patient exhibited allergy to parecoxib sodium.
3. lactating or pregnant.
4. any other conditions not suitable for surgery as evaluated by the surgeon in charge.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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74 participants in 2 patient groups, including a placebo group

Parecoxib sodium

Experimental group

Description:

The patients in the parecoxib group received a single 40mg dose of parecoxib sodium 30 minutes before incision.

Treatment:

Drug: Parecoxib sodium

Normal saline injection

Placebo Comparator group

Description:

The control group received 2 mL normal saline injection at the same time point.

Treatment:

Drug: Normal saline injection