Parental Consanguinity and Family History of Kidney Disease in Turkish Kidney Disease Population (CAKD)

Istanbul University

Status: Completed

Conditions: Hereditary Diseases

Treatments: Other: Patients

Study type: Observational

Funder types: Other

Identifiers

NCT02917070

2016/257

301

Details and patient eligibility

About

Inbreeding and consanguineous marriages are known to increase the risk of autosomal recessive disorders. The aim of this study was to examine the association between consanguinity and kidney diseases in the adult Turkish population.

Full description

This was a national, cross-sectional study recruiting patients from nephrology out-patient clinics and dialysis units. All patients between 18 and 70 years of age who were on follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty from October 2009 to October 2015 were included in the study. All patients and healthy controls enrolled in this study gave informed consent to participate in the survey. They were all asked to answer a questionnaire including socio-demographic data, history of familial kidney disease and consanguineous marriage. Additional information was obtained from their private physicians and medical files. To ensure reliability of administration of the questionnaire, all interviewers underwent training using a standardized protocol.

Enrollment: 2,576 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty
• between 18-70 years old
• provide informed consent

Exclusion criteria

• follow-up shorter than 6 months
• patients whose data were not available
• patients who were unwilling or unable to provide informed consent

Trial design

2,576 participants in 2 patient groups

Patients

Description:

Patients who have chronic kidney diseases

Treatment:

Other: Patients

Healthy controls

Description:

Healthy subjects