Parkinsonism-Related Oscillations in the Cortico-Basal Ganglia-Thalamic Network During Movement: Beyond the Frequency Range (MOVOSCILLCBGT)

University Hospital of Bordeaux

Status: Enrolling

Conditions: Parkinson Disease; Hypokinesia; Hyperkinesis

Treatments: Other: Electrophysiological recordings

Study type: Interventional

Funder types: Other

Identifiers

NCT06438419

CHUBX 2023/63

Details and patient eligibility

About

Expression of hypokinetic and hyperkinetic motor symptoms in Parkinson's disease (PD) is associated with pathological synchronous oscillations of neuronal activity (local field potential/LFP) in the cortico-subcortical network with a wide frequency range. In the present project, we propose to study cortico-subcortical oscillations and their synchronization in patients operated for PD (subthalamic deep brain stimulation (STN-DBS)) during distinct pharmacological and stimulation conditions (hypokinetic and hyperkinetic), using a simple motor task.

Full description

To define the link between the characteristics of neuronal oscillations (frequency, amplitude, phase relationship) within the cortico-subcortical network and the movement, we designed a simple motor task of gripping/pulling a lever. The LFPs will be collected at the cortical and subcortical levels (STN) during the motor task using a high-resolution EEG (HR-EEG) and the Percept™ system (Medtronic). Recordings will be realized in four conditions: without pharmacological treatment and without stimulation (Off condition), without pharmacological treatment and during stimulation (DBS condition), during pharmacological treatment and without stimulation (DOPA condition) and during pharmacological treatment and stimulation (DOPA+DBS condition).

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or Female
• 18 to 75 years-old
• With idiopathic Parkinson's disease
• Having a STN-DBS with a PERCEPT™ for less than a year or being candidate for STN-DBS with the PERCEPT™ device (first-implantation)
• Able to perform the simple motor task
• Patients covered by a health insurance scheme
• Giving free, informed, written consent signed by the participant and the investigator.

Exclusion criteria

• Be incapable of giving consent personally.
• Be subject to a legal protection measure (curatorship, guardianship) or be placed under judicial protection.
• Being pregnant or breastfeeding
• Present a serious and/or decompensated somatic or psychiatric illness.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Recruited patient

Experimental group

Description:

Patient with idiopathic Parkinson's disease and having a STN DBS with a PERCEPT™ for less than a year or being candidate for subthalamic nucleus deep brain stimulation with the PERCEPT™ device (first-implantation)

Treatment:

Other: Electrophysiological recordings