Parkinson´s Disease, Aerobic Exercise and Photobiomodulation (PDAERPBM)

University of Oviedo

Status: Completed

Conditions: Parkinson Disease

Treatments: Other: Aerobic training; Other: Photobiomodulation

Study type: Interventional

Funder types: Other

Identifiers

NCT05152706

No. 295/19

Details and patient eligibility

About

The aim of the present study was to assess the effects of a combined therapy of aerobic exercise and transcranial photobiomodulation upon the cardinal motor sympomts of Parkinson´s disease of a group of Parkinson´s disease patients. It was hypothesized that aerobic exercise and transcranial photobiomodulation would yield significant benefits in the cardinal motor sympomts of the illness.

Enrollment: 72 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis with idiopathic PD and rated 1-2 on the Hoehn and Yahr Scale.
• No type of dementia as assessed by the mini-mental state examination.
• Able to stand for 2 min without assistance.
• Able to walk 10 m without assistance.

Exclusion criteria

• Individuals were excluded if they suffered a neurological disease other than PD, if the subject has an implant of any kind in the head (e.g., stent, clipped aneurysm, embolized arteriovenous malformation, implantable shunt - Hakim valve) or if they did not meet the eligibility criteria.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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72 participants in 4 patient groups

Intervention aerobic (IAER)

Experimental group

Description:

Patients assigned to the IAER participated in fourty-eigth aerobic exercise therapy sessions over the course of six months.

Treatment:

Other: Aerobic training

Intervention photobiomodulation (IPBM)

Experimental group

Description:

Patients assigned to the IPBM participated in fourty-eigth transcraneal photobiomodulation (PBM) theraphy sessions, using a therapeutic laser console, over the course of six months.

Treatment:

Other: Photobiomodulation

Intervention aerobic and photobiomodulation (IAER+PBM9

Experimental group

Description:

Patients assigned to the IAER+PBM participated in the aerobic exercise therapy and the PBM one at the same time, during six months.

Treatment:

Other: Photobiomodulation

Other: Aerobic training

Control (CO)

No Intervention group

Description:

Patients assigned to the control (CO) did not participated in any kind of therapy, they just followed their usual weekly routine during six months