Parkinson's Disease, Diagnostic Observations (PADDO)

Radboud University Medical Center

Status: Unknown

Conditions: Parkinson's Disease; Atypical Parkinsonism

Study type: Observational

Funder types: Other

Identifiers

NCT01249768

PADDO

Details and patient eligibility

About

Background:

Parkinson's Disease and the Atypical Parkinsonian Disorder (like Multiple System Atrophy, Progressive Supranuclear Palsy, Corticobasal Degeneration, Lewy Body Dementia) are disease entities with partly common symptomatology. Especially very early in the course of disease, the differentiation between both disease entities can be challenging, even for specialists in the field of movement disorder. However, the establishment of a correct diagnosis is very important for adequate patientcounseling, treatment and the correct inclusion of patients in research trials. Ancillary diagnostic investigations are looked upon to aid in this diagnostic dilemma.

Objective:

To investigate the value of ancillary diagnostic investigations, more specific MRI, analysis of cerebrospinal fluids and a second opinion in a specialized movement disorder centre, to differentiate Parkinson's disease and the Atypical Parkisonisonian disorder.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hypokinetic rigid syndrome
• Disease duration of maximum 36 months

Exclusion criteria

• Probable diagnosis of PD without any red flags
• Probable diagnosis MSA
• Probable diagnosis PSP
• Diagnosis CBD
• Diagnosis DLB
• Probable diagnosis Vascular Parkinsonism
• Other neurodegenerative disease than parkinsonism
• A prior history of brain surgery
• Instable comorbidity

Trial design

150 participants in 1 patient group

Cohort

Description:

The cohort will consist of 150 patients with a hypokinetic rigid syndrome and a disease duration of maximum 36 months