Paroxetine and Interpersonal Psychotherapy for Maintaining Health and Well-being in Elderly Individuals With Depression

University of Pittsburgh

Status and phase

Completed

Phase 4

Conditions

Unipolar Depression

Treatments

Behavioral: Interpersonal Psychotherapy

Drug: paroxetine

Study type

Interventional

Funder types

Other

Identifiers

NCT00178100

R01MH043832-02

971156

DATR A4-GPS

Details and patient eligibility

About

This study will evaluate the effectiveness of paroxetine versus interpersonal psychotherapy and a combination of the two in helping elderly patients with depression remain well and improve quality of their lives.

Full description

This is primarily a study of maintenance therapies, not a study of acute therapeutic efficacy, in late-life major depression. The study aims to identify factors that encourage maintenance of treatment gains and to identify which patients need which kinds of treatment to remain well. The following questions are to be addressed:

Is the probability of recurrence different among the treatment groups?
What variables may be related to, or predictive of, differences among groups?
After 1 to 2 years of maintenance therapy, will patients assigned to maintenance combined treatment with both paroxetine and interpersonal psychotherapy remain well at higher rates than patients assigned to paroxetine alone, interpersonal psychotherapy alone, or placebo?
Will the time to recurrence differ across treatment groups, and what variables may be related to, or predictive of, time to recurrence?

The major study hypothesis is that combined treatment with paroxetine and interpersonal psychotherapy will be superior to either treatment alone (and to placebo) in preventing recurrence of major depressive episodes in patients aged 70 and above.

For information on related studies, please follow these links:

http://clinicaltrials.gov/show/NCT00000377

http://clinicaltrials.gov/show/NCT00177671

Sex

All

Ages

69+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria