Partial Rebreathing in the Treatment of Migraine With Aura (CapnoMigra)

University of Aarhus

Status: Completed

Conditions: Migraine With Aura

Treatments: Device: Dummy partial rebreathing device; Device: Active partial rebreathing device

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03472417

2016-003683-39

Details and patient eligibility

About

A study to test the efficacy of a partial rebreathing device in treating and/or preventing migraine pain

Enrollment: 18 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Migraine with aura
• Attack frequency of between one and six migraine-with-aura attacks per month over the last six months
• Adults (18-60 years)
• Age at onset of migraine < 50 years
• If taking migraine prophylactic drugs, the dosis must have been stable for > 3 months
• Must speak and understand Danish

Exclusion criteria

• • Cardiovascular disease, pulmonary disease, metabolic acid/base disorder, cancer, moderate and severe depression, anemia or other blood disease
• Chronic migraine, i.e. more than 15 headache days per month over the last three months
• Medication overuse headache
• More than six migraine-with-aura attacks per month
• Non-migraine headache on more than six days per month
• A typical duration between migraine-with-aura attacks of less than 48 hours

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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18 participants in 2 patient groups

Active partial rebreathing device

Active Comparator group

Treatment:

Device: Active partial rebreathing device

Dummy partial rebreathing device

Sham Comparator group

Treatment:

Device: Dummy partial rebreathing device