PAS for Lower Extremity Rehabilitation in Tetraplegic Patients

Helsinki University Central Hospital (HUCH)

Status: Completed

Conditions: Spinal Cord Injuries; Spinal Cord Diseases

Treatments: Device: Paired associative stimulation (with eXimia magnetic stimulator and Dantec Keypoint® electroneuromyography device)

Study type: Interventional

Funder types: Other

Identifiers

NCT03459885

UAK 1022001

Details and patient eligibility

About

The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1,2). In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete cervical level SCI and investigate its effectiveness for lower extremity rehabilitation.

Enrollment: 5 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• cervical incomplete SCI

Exclusion criteria

• epilepsy
• metal inclusion in the head area
• pacemaker
• hearing device
• high intracranial pressure

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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5 participants in 1 patient group

PAS

Experimental group

Description:

The intervention is given to peripheral nerve - motor cortex pairs selected by the investigator.

Treatment:

Device: Paired associative stimulation (with eXimia magnetic stimulator and Dantec Keypoint® electroneuromyography device)