Passive Leg Raising - an Important Diagnostic Manoeuvre (PLR-ANS)

Region MidtJylland Denmark

Status: Completed

Conditions: Cardiovascular Insufficiency

Treatments: Diagnostic Test: Passive Leg Raising

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03454802

619909

Details and patient eligibility

About

The aim is to describe the physiological background for PLR and the interpretation of a PLR manoeuvre.

The protocol entails the measurement of stroke volume (SV) at baseline (semirecumbent patient position), during PLR and after returning to semirecumbent position. Simultaneously blood pressure (BP), pulse rate (PR), pulse oximetric saturation (SpO2) and ECG are recorded. The procedure is performed in ten normal subjects, ten patients recruited in the cardiology outpatient department and ten critically ill patients under analgosedation in the ICU.

Analysis includes changes in measured variables and heart rate variability in the frequency domain during the three phases of the experiment.

Full description

See above

Enrollment: 11 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Consenting after written and oral information

Exclusion criteria

Contraindications to PLR: intracranial or abdominal hypertension

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Sequential Assignment

Masking: Single Blind

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11 participants in 3 patient groups

Normal subjects

Active Comparator group

Description:

Normal subjects 'Passive Leg Raising'

Treatment:

Diagnostic Test: Passive Leg Raising

ICU patients

Active Comparator group

Description:

ICU patients 'Passive Leg Raising'

Treatment:

Diagnostic Test: Passive Leg Raising

Cardiac Outpatients

Active Comparator group

Description:

Cardiac Outpatients 'Passive Leg Raising'

Treatment:

Diagnostic Test: Passive Leg Raising