Passive Smoking and LL-37 in Children

Kırıkkale University

Status: Completed

Conditions: Innate Immunity; Periodontal Health

Study type: Observational

Funder types: Other

Identifiers

NCT03639376

2016/140

Details and patient eligibility

About

This study investigates the salivary LL-37 in passive smoking-exposed and unexposed children and the association between salivary LL-37 levels and periodontal clinical parameters in these children.Unstimulated salivary samples were collected from 180 children (90 passive smoking-exposed and 90 passive smoking-unexposed)

Full description

Diverse mechanisms conduce to the detrimental periodontal effects of passive smoking, including alteration of both microbial and host response factors.

Antimicrobial peptides are considered to be an important intermediate step in initiating an initial immune response against the microbial side of the oral gingival epithelium and in the transition to acquired immunity.

LL-37 has a wide antimicrobial activity against both cariogenic and periopathogenic bacteria and its role in maintaining oral health has recently been stated

Enrollment: 180 patients

Sex: All

Ages: 6 to 12 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Systemically healthy children

Exclusion criteria

• Any medications known to affect defense system and periodontium
• The presence of orthodontic / intraoral appliance

Trial design

180 participants in 2 patient groups

Passive smoking-exposed children

Description:

This group consists of children whose family members have smoked at home since the birth of the child.

Passive smoking-unexposed children

Description:

This group consists of children whose family members have not smoked at home since the birth of the child.