Pathogenesis and Inflammatory Phenotype of Allergic Bronchopulmonary Aspergillosis

Qianfoshan Hospital

Status: Enrolling

Conditions: Allergic Bronchopulmonary Aspergillosis (ABPA)

Study type: Observational

Funder types: Other

Identifiers

NCT07040332

QFS-2025-074

Details and patient eligibility

About

This study aims to reveal the immune and inflammatory regulatory molecular mechanisms related to the progression of allergic bronchopulmonary aspergillosis (ABPA), and to build a precision typing based on inflammation and identify the biomarkers of typing, and to explore the clinical outcomes of different inflammatory phenotypes.

Enrollment: 140 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Meets the diagnostic criteria for allergic bronchopulmonary aspergillosis.
• Meets the diagnostic criteria for fungal-sensitized asthma.

Exclusion criteria

• Human immunodeficiency virus infection.
• Malignant tumor.
• Blood system disease.
• autoimmune system disease.
• History of pulmonary tuberculosis.
• Patients with a history of smoking or still smoking.
• Invasive pulmonary fungal disease.
• Contraindications electronic bronchoscopy

Trial design

140 participants in 3 patient groups

allergic bronchopulmonary aspergillosis

fungal-sensitized asthma

control group