Pathogenic Mechanisms of Port Wine Stain and Repository of Port Wine Stain Biopsy Samples

University of California Irvine (UCI)

Status: Completed

Conditions: Port-Wine Stain

Treatments: Other: Biopsy sample from Port Wine Stain Birthmark

Study type: Interventional

Funder types: Other

Identifiers

NCT02051101

20139396

Details and patient eligibility

About

The purpose of this study is to investigate the pathogenic mechanisms of Port Wine Stain, collect biopsy samples and blood samples to characterize exosomes and metabolites from Port Wine Stain.

Full description

The researcher can detect the defects in nervous system innervation to cutaneous blood vessels contribute to the pathogenesis of Port Wine Stain . Unveiling the pathogenic mechanisms of PWS is crucial to the design of new therapeutic strategies and can use the results to improve current PWS therapeutic outcomes.

Enrollment: 19 patients

Sex: All

Ages: 1+ day old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male or female of all ages.
• Not pregnant.
• Has diagnosis of port wine stain on the arms, legs, chest, bac.
• Ability to understand and carry out subject instructions.
• Subject willing to have skin biopsies on port wine stain and normal skin areas.

Exclusion criteria

• Pregnant women.
• Port Wine Stain on the face.
• History of skin cancer.
• Current participation in an investigational drug evaluation
• Concurrent use of known photosensitizing drugs.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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19 participants in 1 patient group

Port Wine Stain Birthmark

Other group

Description:

Biopsy sample from Port Wine Stain Birthmark

Treatment:

Other: Biopsy sample from Port Wine Stain Birthmark