Pathogenic Study of Adult Immune Enteropathies (ENTEROPATH)

Institut National de la Santé Et de la Recherche Médicale, France

Status: Enrolling

Conditions: Celiac Disease; Autoimmune Enteropathy; Inflammatory Bowel Diseases

Treatments: Genetic: Blood sample collection; gastrointestinal biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT04280510

2019-A01594-53 (Registry Identifier)

C19-07

Details and patient eligibility

About

The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 years or over
• affiliated to social insurance
• signed informed consent

Exclusion criteria

• pregnancy
• under guardianship
• not able to sign informed consent

Trial design

200 participants in 7 patient groups

Active coeliac patients

Description:

Patients with active coeliac disease

Treatment:

Genetic: Blood sample collection; gastrointestinal biopsy

Treated coeliac patients

Description:

Patients with coeliac disease on gluten free diet

Treatment:

Genetic: Blood sample collection; gastrointestinal biopsy

Sprue type I

Description:

Patients with refractory coeliac disease of type I

Treatment:

Genetic: Blood sample collection; gastrointestinal biopsy

Sprue type II

Description:

Patients with refractory coeliac disease of type II

Treatment:

Genetic: Blood sample collection; gastrointestinal biopsy

Intestinal Lymphoproliferations

Description:

Patients with intestinal lymphoproliferations

Treatment:

Genetic: Blood sample collection; gastrointestinal biopsy

Non coeliac enteropathies

Description:

Patients with non coeliac immune-mediated enteropathy

Treatment:

Genetic: Blood sample collection; gastrointestinal biopsy

Patients without neoplastic or inflammatory intestinal disease

Description:

Patients without neoplastic or inflammatory intestinal disease

Treatment:

Genetic: Blood sample collection; gastrointestinal biopsy