Pathophysiologic Changes in the Respiratory System After Fire Smoke Inhalation

University of Oslo (UIO)

Status: Completed

Conditions: Bronchial Asthma

Treatments: Other: Fiberoptic bronchoscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT01240707

REK S-O, Ref 2010/1340, part A

Details and patient eligibility

About

Fire smoke inhalation may contribute to intrabronchial inflammation, airway obstruction and impaired gas exchange. In this study the investigators will examine if the scope of inhalation injury can be assessed soon after hospital admission based on clinical markers, biochemical markers, Peak Expiratory Flow (PEF), spirometry and bronchoscopy. At 6 months a lung function test and metacholine test will be performed to examine whether patients have developed increased bronchial hyperreactivity (asthma) or not after the initial fire smoke exposure.

Full description

Fire smoke inhalation may contribute to intrabronchial inflammation, airway obstruction and impaired gas exchange. The scope of injury in fire smoke victims ranges from cough and minor airway irritation to severe respiratory failure and long term mechanical ventilation in the Intensive Care Unit. Some patients with high HbCO-levels are also treated with hyperbaric oxygen therapy.

In this study the investigators will examine if the scope of inhalation injury can be assessed soon after admission based on clinical markers, biochemical markers, Peak Expiratory Flow (PEF), spirometry and bronchoscopy. The clinical effect of fiberoptic bronchoscopy after severe smoke inhalation will also be examined. At 6 months a lung function test and metacholine test will be performed to examine whether they have developed asthma/increased bronchial hyperreactivity or not after the initial fire smoke exposure. Lab staff (flowcytometer and cytokine analysis) are unaware of patient identity and whether the patient is a smoke-exposed patient or a healthy volunteer in the control group of non-exposed persons.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• fire smoke exposed patient
• > 18 years of age
• admitted to hospital

Exclusion criteria

• < 18 years of ager
• trauma patient

Control group (healthy volunteers/hospital staff):

• > 18 years of age
• non-smoker
• no exposure to fire smoke

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

LF tests, Fiberoptic bronchoscopy

Other group

Description:

Spirometry, Peak Expiratory Flow (PEF). Bronchoscopic assessment of soot in central airways.

Treatment:

Other: Fiberoptic bronchoscopy