Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot and Other Congenital Heart Diseases (PACT)

Mayo Clinic

Status: Enrolling

Conditions: Tetralogy of Fallot; Congenital Heart Disease

Treatments: Diagnostic Test: Remote Heart Rhythm Monitoring

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT05122962

R01HL158517 (U.S. NIH Grant/Contract)

21-005062

Details and patient eligibility

About

This study is being done to determine the mechanism(s) contributing to the onset of symptoms (i.e. shortness of breath and/or palpitations) as well as changes in heart structure in patients with congenital heart disease (CHD)

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Moderate (or greater) PR based on quantitative Doppler echocardiography.
• Repaired TOF
• Congenital Heart Disease diagnosis including but not limited to Ebstein's anomaly, coarctation of the aorta (COA), Fontan palliation, transposition of the great arteries, congenitally corrected transposition of the great arteries.

Exclusion criteria

• Pregnant Women
• Unable to undergo CMRI