Pathophysiology of Gas Exchange and Time Course Changes in Spontaneously Breathing Patients With Acute Respiratory Failure Due to COVID-19. A Multicenter Prospective Study. (COVAQ)

CHU de Reims

Status: Unknown

Conditions: Respiratory Insufficiency

Treatments: Other: Pathophysiology of gas exchange

Study type: Interventional

Funder types: Other

Identifiers

NCT05392062

PO21075

Details and patient eligibility

About

The pathophysiology of SARS-COV-2 related respiratory disease is still poorly understood, especially in its most severe form called acute respiratory distress syndrome (ARDS). In this case, very few studies have investigated changes in gas exchange during COVID-19 progression in spontaneously breathing patients. The investigators purpose in this study to explore the pathophysiology of gas exchange and time course changes in spontaneously breathing patients with acute respiratory failure due to COVID-19. Moreover, our aim is to identify early markers associated with worsening respiratory failure and requiring endotracheal intubation.

Enrollment: 156 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

inclusion criteria :

• Patients with a COVID-19 confirmed infection.
• Admission in intensive care unit for an acute respiratory failure requiring oxygen flow above 6l/min by facial mask.
• Presence of an arterial catheter for blood sampling.

exclusion criteria :

• Patients on mechanical ventilation on admission to the ICU.
• Patients requiring immediate intubation on admission.
• Patients admitted to the ICU for more than 48 hours at the time of inclusion.
• Pulmonary embolism diagnosed before admission to the ICU.
• Minor patients
• Pregnant women
• Patients under curatorship or guardianship
• Persons deprived of liberty by a judicial or administrative decision

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

156 participants in 1 patient group

Respiratory insufficiency

Other group

Description:

Subject with respiratory insufficiency

Treatment:

Other: Pathophysiology of gas exchange