Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU)

University of Zurich (UZH)

Status: Completed

Conditions: Hypertensive Ischemic Leg Ulcer; Calciphylaxis

Study type: Observational

Funder types: Other

Identifiers

NCT01578382

KEK-ZH-NR2010-0433/0

Details and patient eligibility

About

Martorell hypertensive ischemic leg ulcer is a severe type of skin necrosis (skin infarction) which occurs in long-term hypertensive subjects.

Calciphylaxis (calcific uremic arteriolopathy) is a severe type of skin necrosis (skin infarction) which occurs in subjects with end-stage kidney disease or after kidney transplantation.

Full description

Comparative study including

• 20 consecutive patients with Martorell HYTILU
• 10 consecutive patients with Calciphylaxis (calcific uremic arteriolopathy)
• 20 patients with venous ulcer

The following parameters are measured in the blood serum:

White blood count; c-reactive protein; creatinine; calcium (total); free (ionized) calcium; phosphate; albumin; 25-hydroxyvitamin-D; 1-25-dihydroxyvitamin-D; homocysteine; cystatin C alphafetoin, osteoprotegerin; fibroblast growth factor 23 (FGF-23); globular arrest 1 (GLA-1)

The following parameters are measured in samples of diseased (necrobiotic) skin:

alphafetoin, osteoprotegerin; fibroblast growth factor 23 (FGF-23); globular arrest 1 (GLA-1)

Enrollment: 120 patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Having Martorell hypertensive ischemic leg ulcer (as defined above) or
• Having Calciphylaxis (calcific uremic arteriolopathy (as defined above) or
• Having a venous ulcer (as defined above)

Exclusion criteria

• None

Trial design

120 participants in 3 patient groups

Hypertensive ischemic leg ulcer

Description:

Twenty consecutive patients with Martorell HYTILU as defined in: Arch Dermatol 2010;146:961-968

Calciphylaxis

Description:

Ten subjects with calciphylaxis (calcific uremic arteriolopathy) as described in: Vasa 1998;27:137-143

Venous ulcer (controls)

Description:

Twenty subjects with venous ulcers (CEAP C4-6) as described in: J Vasc Surg. 2004 Dec;40(6):1248-52