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Pathophysiology of Orthostatic Intolerance

S

Satish R. Raj

Status

Active, not recruiting

Conditions

Tachycardia
Postural Orthostatic Tachycardia Syndrome

Treatments

Drug: Intrinsic Heart Rate
Radiation: DAXOR
Procedure: QSweat

Study type

Interventional

Funder types

Other
NIH

Identifiers

Details and patient eligibility

About

The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed that many different pathophysiological processes can give rise to this disorder.

Full description

The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed that many different pathophysiological processes can give rise to this disorder.

This is not a clinical trial in the classical sense, but an omnibus protocol to allow for disntinct and personalized pathophysiological testing.

Enrollment

260 patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Orthostatic intolerance

Exclusion criteria

  • Inability or unwillingness to give informed consent

Trial design

Primary purpose

Diagnostic

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

260 participants in 2 patient groups

Patients
Other group
Description:
Patients with orthostatic intolerance
Treatment:
Procedure: QSweat
Drug: Intrinsic Heart Rate
Radiation: DAXOR
Healthy Control Subjects
Other group
Description:
Healthy subjects to determine "normal" response
Treatment:
Procedure: QSweat
Drug: Intrinsic Heart Rate
Radiation: DAXOR

Trial contacts and locations

1

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Central trial contact

Bonnie K Black, BSN CNP

Data sourced from clinicaltrials.gov

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