Patient-centred Deprescribing of Psychotropic, Sedative and Anticholinergic Medication in Elderly Patients With Polypharmacy (PARTNER)

Ludwig Maximilian University of Munich

Status: Enrolling

Conditions: Antipsychotic Agents; Antidepressive Agents; Cholinergic Antagonists; Analgesics, Opioid; Hypnotics and Sedatives; Deprescriptions

Treatments: Behavioral: PARTNER intervention; Behavioral: Control intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT05842928

01VSF21038

Details and patient eligibility

About

The PARTNER study is a multicentre, two-arm, pragmatic cluster-randomised trial evaluating the impact of a focused and patient-centred cooperation between general practitioners (GPs) and community pharmacists (PARTNER intervention) on reductions in the use of psychotropic, sedative and anticholinergic potentially inappropriate medication (PSA-PIM) compared to a control intervention. The PARTNER intervention comprises (1) education for health care professionals, (2) an interprofessional workshop and case conference, (3) a pharmacy visit with brown bag/medication review and patient empowerment, (4) GP practice visit with shared decision making. The control intervention only comprises a pharmacy visit with brown bag review.

Enrollment: 352 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 65 years or older
• Patient is capable of giving consent
• GP contact in the quarter prior to inclusion
• Current use of ≥ 5 drugs, including ≥ 1 PSA-PIM (hypnotics, opioids, gabapentinoids, antipsychotics, antidepressants, anticholinergic urospasmolytics) with a treatment duration of ≥ 6 months
• Willingness to select a regular pharmacy for the study period
• Consent to data exchange between GP and community pharmacy

Exclusion criteria

• Terminal illness (life expectancy < 6 months)
• Current treatment of pain associated with cancer
• Other serious physical illness or mental distress (e.g. bereavement) that makes participation in the study impossible (according to the GP's assessment)
• Psychiatric illness or addiction that makes participation in the study impossible (according to the GP's assessment)
• Unable to meet the requirements of the study (participation in telephone or written questionnaires, visits to the GP practice or community pharmacy, alone or with the help of caregivers for physical infirmity)
• Current participation in research projects on medication safety or geriatric medicine

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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352 participants in 2 patient groups

Intervention Arm

Experimental group

Description:

Intensified and patient-centred cooperation between GPs and pharmacists including patient empowerment

Treatment:

Behavioral: PARTNER intervention

Control Arm

Active Comparator group

Description:

Extended routine care

Treatment:

Behavioral: Control intervention